![]() Further testing should include blood cultures, lactate dehydrogenase, creatine kinase, rheumatoid factor, and antinuclear antibodies. ![]() If there are no potentially diagnostic clues, the patient should undergo a minimum diagnostic workup, including a complete blood count, chest radiography, urinalysis and culture, electrolyte panel, liver enzymes, erythrocyte sedimentation rate, and C-reactive protein level testing. ![]() Clinicians should perform a comprehensive history and examination to look for potentially diagnostic clues to guide the initial evaluation. The most common subgroups in the differential are infection, malignancy, noninfectious inflammatory diseases, and miscellaneous. Fever of unknown origin is more often an atypical presentation of a common disease rather than an unusual disease. Although there are more than 200 diseases in the differential diagnosis, most cases in adults are limited to several dozen possible causes. A more recent qualitative definition requires only a reasonable diagnostic evaluation. Fever of unknown origin has been described as a febrile illness (temperature of 101☏ or higher) for three weeks or longer without an etiology despite a one-week inpatient evaluation.
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